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. 2016 Aug 2;99(2):470–480. doi: 10.1016/j.ajhg.2016.06.017

Figure 6.

Figure 6

Expression Analysis of NFE2L2, CUL3, and Four NRF2 Target Genes

The expression of NFE2L2, CUL3, RXRA, SLC25A25, and IDH1 was significantly lower in two affected individuals (V:1 and V:2 from F1) than in six healthy control individuals (respective p values are 0.001, 0.005, 0.001, 0.026, and 0.002). For EPHX1, the observed decrease was not significant (p value of 0.076). qPCR expression analysis was performed as previously described.25 Error bars represent the SE of the relative quantities.