Table 2.
The Odds Ratio of the Three Environmental Factors Associated with SNP Genotypes for Barrett’s Esophagus and Esophageal Adenocarcinoma, and the Three Score Tests for Multiple G × E Simultaneously
|
OR Stratified by the Number of Minor Alleles |
G × E p Value |
|||||||
|---|---|---|---|---|---|---|---|---|
| Disease | Risk Factor | 0 | 1 | 2 | Unconstrained | One-Sided | Bidirectional | Proportional |
| rs11765529 | ||||||||
| BE | BMI | 1.94 (1.74, 2.17) | 1.64 (1.24, 2.16) | 1.28 (0.08, 19.7) | – | – | – | – |
| smoking | 1.67 (1.41, 1.98) | 0.79 (0.51, 1.21) | 0.94 (0.80, 11.1) | – | – | – | – | |
| GERD | 6.39 (5.35, 7.64) | 2.09 (1.36, 3.21) | 0.69 (0.06, 8.09) | 3.48 × 10−9 | 7.10 × 10−10 | 1.42 × 10−9 | 1.81 × 10−9 | |
| EA | BMI | 1.51 (1.31, 1.74) | 1.17 (0.81, 1.69) | – | – | – | – | – |
| smoking | 1.87 (1.50, 2.35) | 1.20 (0.64, 2.27) | – | – | – | – | – | |
| GERD | 3.83 (3.07, 4.77) | 2.34 (1.33, 4.11) | – | 0.013 | 0.004 | 0.0072 | 0.003 | |
| rs4930068 | ||||||||
| BE | BMI | 2.11 (1.80, 2.49) | 1.91 (1.64, 2.22) | 1.32 (1.01, 1.72) | – | – | – | – |
| smoking | 1.56 (1.22, 1.99) | 1.73 (1.38, 2.18) | 0.85 (0.56, 1.28) | – | – | – | – | |
| GERD | 7.91 (6.08, 10.30) | 4.75 (3.76, 6.02) | 2.86 (1.88, 4.35) | 1.53 × 10−6 | 3.38 × 10−7 | 6.76 × 10−7 | 3.51 × 10−8 | |
| EA | BMI | 1.46 (1.19, 1.79) | 1.43 (1.17, 1.74) | 1.41 (0.99, 1.99) | – | – | – | – |
| smoking | 2.14 (1.54, 2.99) | 1.67 (1.23, 2.27) | 1.08 (0.60, 1.95) | – | – | – | – | |
| GERD | 4.80 (3.48, 6.60) | 3.04 (2.26, 4.08) | 2.21 (1.24, 3.92) | 0.007 | 0.002 | 0.004 | 0.004 | |
Abbreviations are as follows: BE, Barrett’s esophagus; EA, esophageal adenocarcinoma.