Table 3. Results.
| SNIPPV success (n = 58) | SNIPPV failure (n = 20) | p | |
|---|---|---|---|
| GA (median; IQR) | 26.7; 25.9–28.2 | 26.9,25.7–27.9 | 0.506 |
| Weight at birth (median; IQR) | 885; 667–885 | 765; 550–887 | 0.175 |
| Days of life (median; IQR) | 16; 8.0–48.2 | 18.5; 1.7–29.5 | 0.357 |
| Prenatal corticosteroids, n(%) | 49 (84.5) | 15 (75) | 0.635 |
| Rate of intubation at delivery, n(%) | 28 (48.3) | 13 (65) | 0.326 |
| Surfactant, n(%) | 49 (84.4) | 95% (19) | 0.279 |
| Days on MV prior to SNIPPV use (median; IQR) | 7; 1.0–24.0 | 7; 1.0–30.0 | 0.917 |
| nCPAP failure indication, n (%) | 35 (60.3) | 18 (90) | 0.014 |
| Time on SNIPPV support (h) (median; IQR) | 72; 48.0–120.0 | 5.5; 2.2–12.0 | <0.01 |
| Death or BPD (II–III), n (%) | 28 (48.3) | 13 (65) | 0.497 |
| Pathologic cranial ultrasound,a n (%) | 10(17.2) | 4(20) | 0.782 |
| NEC,b n (%) | 7(12.1) | 5(26.3) | 0.139 |
| ROP,c n (%) | 11(19.3) | 3(16.3) | 0.210 |
| PDA,d n (%) | 17 (29.3) | 8(42.1) | 0.310 |
| Oxygen treatment (d) Median (IQR) | 62 (45–95) | 65 (59.7–202.5) | 0.127 |
| Oxygen at discharge, n (%) | 14 (24.1) | 8 (42.1) | 0.149 |
| Death, n (%) | 5 (8.6) | 3 (15.8) | 0.497 |
Abbreviations: BPD, bronchopulmonary dysplasia; GA, gestational age; IQR, interquartile range; MV, mechanical ventilation; nCPAP, nasal continuous positive airway pressure; NEC, necrotizing enterocolitis; ROP, retinopathy of prematurity; PDA, patent ductus arteriosus; SNIPPV, synchronized nasal intermittent positive pressure ventilation.
a
Intraventricular hemorrhage grade 3 or 4 based on Papile's classification or persistent periventricular leukomalacia (more than 15 days).
b
Requiring surgery.
c
Requiring laser therapy.
d
Requiring surgical or percutaneous closure.