Table 4. Outcomes in infants of less than 32 weeks' GA since implementation of SNIPPV use protocol.
| 2012 (n = 117) | 2015 (n = 95) | p-Value | |
|---|---|---|---|
| GA (wk) | 28.9 (27.1–31) | 28.0 (26.1–29.7)) | 0.069 |
| Weight (g) | 1,140 (880–1,502) | 1,000 (750–1,350) | 0.003 |
| Intubation first 2 h | 29 (24.8) | 35 (36.8) | 0.062 |
| Crib score | 1 (0–4) | 3 (1–7) | 0.005 |
| Time on MV (h), mean (SD) | 198 (551.2) | 214 (458.9) | 0.580 |
| SNIPPV use | 1 (0,9) | 26 (27.7) | <0.001 |
| No MV during hospitalization | 39 (41.9) | 43 (45.3) | 0.453 |
| Noninvasive failurea | 39 (33.4) | 17 (17.8) | 0.022 |
| Surfactant treatment | 62 (53) | 60 (63.2) | 0.136 |
| HFOV on day 3 | 15 (12.8) | 23 (24.2) | 0.045 |
| PDA | 38 (33.6) | 37 (39.2) | 0.393 |
| Air leaks | 9 (7.7) | 9 (9.5) | 0.644 |
| Nosocomial sepsis | 76 (65) | 42 (44.2) | 0.008 |
| Pathologic cranial ultrasound | 13 (11.1) | 18 (18.9) | 0.108 |
| SF-BPD global | 73 (62.4) | 63 (66.3) | 0.359 |
| SF-BPD < 26 wk | 11.1% | 15.8% | 0.677 |
| SF-BPD: 26–29 wk | 48.8% | 70% | 0.05 |
| SF-BPD > 29 wk | 89.3% | 88.9% | 0.952 |
| Death or severe BPD | 27 (23) | 18 (18.3) | 0.776 |
| Mortality | 18 (15.4) | 14 (14.7) | 0.320 |
Abbreviations: BPD, bronchopulmonary dysplasia; GA, gestational age; HFOV, high-frequency oscillatory ventilation; MV, mechanical ventilation; SNIPPV, synchronized nasal intermittent positive pressure ventilation; PDA, patent ductus arteriosus; SD, standard deviation; SF, survival-free.
a
In infants managed at birth with noninvasive support.
Note: Data expressed in n (%) or median (IQR).