Figure 4.
KIR Gene-Content and Copy-Number Genotypes
(A) Gene-content genotypes derived from all 97 cell lines by the PING pipeline. A black box indicates that a gene is present, and a clear box indicates the absence of a gene. One example from each observed gene-content genotype (GC type) is shown, and the number observed is shown on the right.
(B) Independent validation of the KIR copy-number genotypes by real-time PCR12 on 85 samples. There were four discrepancies due to alleles undetected by real-time PCR (allele). There were two false positives (pos) and two false negatives (neg) by real-time PCR. Two discrepancies remain unexplained.
(C) Gene copy-number genotypes derived from all 97 cell lines by PING_gc. A colored rectangle indicates the presence of a gene, and the shades represent the copy number as indicated in the key. One example from each observed gene copy-number genotype (CN type) is shown, and the number observed is shown on the right.