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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Curr Opin Nephrol Hypertens. 2016 Sep;25(5):444–451. doi: 10.1097/MNH.0000000000000252

Figure 3.

Figure 3

Proposed model for the negative feedback of vasopressin stimulated UT-A1 activity by 14-3-3ɣ. This schematic shows vasopressin (AVP) binding to the type 2 vasopressin receptor (V2R) and stimulating cAMP production, which stimulates PKA to activate/phosphorylate UT-A1. It also shows the PKA stimulation of 14-3-3ɣ which then binds to UT-A1 promoting ubiquitination (Ub) and subsequent degradation, effectively reversing the original PKA-mediated activation. The data showing these opposite effects of PKA are established, but whether there is a negative feedback loop, or whether only one effect is dominant in vivo, remains to be determined.