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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Curr Opin Nephrol Hypertens. 2016 Sep;25(5):436–443. doi: 10.1097/MNH.0000000000000255

Figure 4. Effect of NBCe1 deletion on urinary ammonia and pH.

Figure 4

Top: effects on urine ammonia. Despite the metabolic acidosis associated with NBCe1 gene deletion, ammonia excretion decreased with heterozygous gene deletion and was suppressed significantly further with homozygous deletion. Bottom: effects on urine pH. Urine pH was significantly more acidic (lower) in mice with heterozygous NBCe1 deletion than in wild-type mice and was decreased significantly further by homozygous NBCe1 deletion. Figure originally published in [28] and reprinted with permission.