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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Curr Opin Nephrol Hypertens. 2016 Sep;25(5):436–443. doi: 10.1097/MNH.0000000000000255

Figure 5. Effect of NBCe1 deletion on NaDC1 expression.

Figure 5

NaDC1 is an apical Na+-coupled citrate transporter present in the proximal tubule that is thought to the primary mechanism regulating urinary citrate excretion. NBCe1 deletion decreased NaDC1 mRNA (left panels) and immunolabel expression (right panels). This effect was unrelated to the associated metabolic acidosis, as experimental metabolic acidosis in the absence of NBCe1 gene deletion increased NaDC1 mRNA and immunolabel expression. Figures 2 (left panel) and 3 (right panel) from [29] were combined and are used with permission.