Table 1.
Demographic, clinical, and neuropathologic characteristics of subjects*
| Characteristics | Total n = 1,066 |
|---|---|
| Demographic | |
| Age‐at‐death, years (SD) | 88.4 (SD = 6.6) |
| Sex, female | 691 (65%) |
| Education, years (SD) | 16.3 (3.7) |
| Clinical | |
| Vascular risk factors (present at any time point) | |
| Hypertension | 695 (65%) |
| Diabetes | 224 (21%) |
| Vascular diseases (present at any time point) | |
| Stroke | 235 (22%) |
| Myocardial infarction | 236 (22%) |
| Cognitive conditions | |
| Dementia | 463 (43%) |
| Mild cognitive impairment | 258 (24%) |
| No cognitive impairment | 341 (32%) |
| Neuropathologic | |
| Chronic brain infarcts | |
| Any infarct present | 517 (49%) |
| Microinfarct burden | |
| Single | 186 (17%) |
| Multiple | 114 (11%) |
| Microinfarct region | |
| Cortical | 175 (16%) |
| Subcortical | 167 (15%) |
| Cerebral vessel pathology severity | |
| Atherosclerosis | |
| Low | 481 (45%) |
| Moderate | 338 (32%) |
| Severe | 92 (9%) |
| Arteriolosclerosis | |
| Low | 364 (34%) |
| Moderate | 273 (26%) |
| Severe | 109 (10%) |
| Amyloid Angiopathy | |
| Low | 469 (44%) |
| Moderate | 242 (23%) |
| Severe | 132 (12%) |
*N (%), unless otherwise specified