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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Mult Scler. 2016 Feb 4;22(13):1685–1694. doi: 10.1177/1352458516628656

Table 2.

Variables associated with cognitive impairment defined as two or more test impairments within the MACFIMS battery.

Parameter p-value
Age   0.5101
Gender   0.3732
Education   0.0696
Disease duration   0.9091
HADS-A (log)   0.2567
HADS-D (log)   0.0001
EDSS   0.0144
Overall cortical CBF (regional level) <0.0001
Overall WM CBF (regional level) <0.0001
Overall cortical CBV (regional level) <0.0001
Overall WM CBV (regional level) <0.0001
Overall cortical MTT (regional level)   0.0887
Overall WM MTT (regional level)   0.2101
BPF   0.2058
fC (%)   0.3451
fWM (%)   0.3041
fT2h (%)   0.3667
fT1bh (%)   0.2205
fCSF (%)   0.2004

HADS-A: Hospital Anxiety and Depression Scale–Anxiety; HADS-D: Hospital Anxiety and Depression Scale–Depression; EDSS: Expanded Disability Status Scale; WM: white matter; CBF: cerebral blood flow; CBV: cerebral blood volume; MTT: mean transit time; BPF: brain parenchymal fraction; fC: fractional cortical volume; fWM: fractional white matter; fT2h: fractional white matter T2-hyperintensities; fT1bh: fractional T1 black holes; fCSF: fractional cerebrospinal fluid. p-value < 0.05 was considered statistically significant.