. Author manuscript; available in PMC: 2016 Sep 7.

Published in final edited form as: Biometrics. 2016 Feb 4;72(3):888–896. doi: 10.1111/biom.12480

Table 3.

Simulation studies for seven biomarkers as in the Sjogren Syndrome Study. 210 subjects recruited in each stage. Probability of being a case is 0.35. Results are based on the completed studies from 1000 simulated datasets. The empirical mean (empirical standard error) are given for each estimator of the ROC⁻¹(0.95). Estimators without * used bias correction.

True ROC⁻¹ (0.95)

{\hat{ROC}}^{- 1} {(0.95)}_{stg 1}

{\hat{ROC}}^{- 1} {(0.95)}_{stg 1}

% Early stopping

{\hat{ROC}}^{- 1} {(0.95)}_{all}

{\hat{ROC}}^{- 1} {(0.95)}_{stg 2}

{\hat{ROC}}^{- 1} {(0.95)}_{R B}

0.50

0.4431 (0.1006)

0.4981 (0.1067)

7.0

0.4938 (0.0721)

0.5046 (0.1052)

0.5018 (0.0733)

0.55

0.4917 (0.1017)

0.5478 (0.1068)

16.5

0.5363 (0.0705)

0.5532 (0.1046)

0.5512 (0.0742)

0.60

0.5398 (0.1013)

0.5967 (0.1054)

32.1

0.5782 (0.0694)

0.6044 (0.1032)

0.6017 (0.0771)

0.65

0.5904 (0.0989)

0.6480 (0.1019)

53.7

0.6171 (0.0678)

0.6557 (0.0985)

0.6519 (0.0768)