Table 1.
Methodological characteristic of eligible articles
| Author (Reference) | Number of subjects | Intervention | Study design | Dose of DHEA | Duration |
|---|---|---|---|---|---|
| Barad [13] | 89 cases/101 controls (diminished ovarian reserve) | IVF | Case–control | 75 mg/day | 3.8 ± 0.3 months |
| Barad [12] | 25 self-control (diminished ovarian reserve) | IVF | Prospective cohort study | 75 mg/day | 4.1 ± 0.5 months |
| Sonmezer [23] | 19 self-control (POR) | IVF/ICSI | Prospective cohort study | 75 mg/day | 3-6 months |
| Gleicher [32] | 22 cases/44 controls (diminished ovarian reserve) | None | Case–control | 75 mg/day | 2.4 ± 0.9 months |
| Wiser [14] | 26 cases/25 controls (poor response) | IVF | RCT | 75 mg/day | >2 months |
| Artini [33] | 12 cases/12 controls (POR) | IVF/ICSI | RCT | 75 mg/day | 3 months |
| Moawad [24] | 67 cases/66 controls (poor response) | IVF/ICSI | RCT | 75 mg/day | >3 months |
| Fusi [25] | 38 cases/24 controls and 39 self-controls (poor responses) | IVF | Prospective cohort study | 75 mg/day | >3 months |
| Hyman [26] | 32 self-control (poor responses) | IVF | Prospective cohort study | 75 mg/day | >3 months |
| Singh [27] | 30 self-control (poor responses) | IVF | Prospective cohort study | 75 mg/day | 4 months |
| Yeung [32] | 10 cases/12 control (primary ovarian insufficiency) | IVF | RCT | 75 mg/day | 4 months |
| Yilmaz [36] | 41 self-control (diminished ovarian reserve) | IVF/ICSI | Prospective cohort study | 75 mg/day | >1.5 months |
| Jirge [15] | 25 self-control (POR) | IVF | Prospective cohort study | 75 mg/day | >2 months |
| Kara [28] | 104 cases/104 controls (diminished ovarian reserve) | IVF/ICSI | RCT | 75 mg/day | >3 months |
| Vlahos [2] | 48 cases/113 controls (POR) | IVF | Prospective cohort study | 75 mg/day | >3 months |
| Xu [16] | 189 cases/197 controls (POR) | IVF/ICSI | Case–control | 75 mg/day | 3 months |
| Yeung [6] | 16 cases/16 controls (poor response) | IVF/ICSI | RCT | 75 mg/day | 3 months |
| Zangmo [17] | 50 self-control (poor responses) | IVF | Prospective cohort study | 75 mg/day | 4 months |
| Zhang [29] | 42 cases/42 controls (diminished ovarian reserve) | IVF | RCT | 75 mg/day | 3 months |
| Tartagni [30] | 53 cases/56 controls (poor responses) | IVF | RCT | 75 mg/day | 2 months |
| Tsui [31] | 10 self-control (poor responses) | IVF | Prospective cohort study | 90 mg/day | 3 months |
DHEA dehydroepiandrosterone, POR poor ovarian response, RCT randomized control trials