Table 1.
Embryological and clinical outcomes from oocytes with granular vacuole or bull-eye inclusion
| Parameters | Controls | Granular vacuole | Bull-eye inclusion | p |
|---|---|---|---|---|
| Cycles (n) | 3877 | 211 | 11 | |
| COC (mean, range) | 7.0 ± 4.8 | 9.2 ± 4.8 | 6.9 ± 2.9 | a |
| 0–42 | 1–26 | 3–12 | ||
| Maturation rate | 78.3 | 80.5 | 86.8 | a |
| Fertilization rate | 77.2 | 82.8 | 80.3 | a |
| Embryo cleavage rate | 99.2 | 93.4 | 100 | a |
| Day 3 grade A/B rate | 95.5 | 96.2 | 100 | NS |
| Blastocyst rate | 47.6 | 50.4 | 46.2 | NS |
| Embryo transfer cycles (n) | 3352 | 203 | 10 | |
| No. of embryos transferred (mean, rate) | 1.9 ± 0.5 | 1.8 ± 0.5 | 2.0 ± 0.5 | NS |
| 1–4 | 1–3 | 1–3 | ||
| Biochemical pregnancy (rate per ETC) | 40.7 | 46.3 | 40 | NS |
| Clinical pregnancy (rate per ETC) | 36.7 | 42.9 | 30 | NS |
| Implantation rate | 24.8 | 27.8 | 25 | NS |
| Abortion (rate per CP) | 11.7 | 20.7 | 0 | a |
| OP (rate per ETC) | 31.7 | 34.0 | 30 | NS |
| LBDR (rate per ETC) | 29.2 | 32.5 | 30 | NS |
| Newborn (rate per ETC) | 1218 (36.3) | 75 (36.9) | 5 (50) | NS |
Values in n, rate, mean ± SD, or range. Significance (p < 0.05)
Controls ICSI cycles in which mature metaphase II oocytes did not display a granular vacuole or a bull-eye inclusion, Granular vacuole ICSI cycles in which at least one of the oocytes had a granular vacuole, Bull-eye inclusion ICSI cycles in which at least one of the oocytes displayed a bull-eye inclusion, a controls vs granular vacuole, b controls vs bull-eye inclusion, c granular vacuole vs bull-eye inclusion, NS not significant, COC cumulus-oocyte complexes (aspirated oocytes), ETC embryo transfer cycles, CP clinical pregnancy, OP ongoing pregnancy, LBDR live birth delivery rate, NB newborn