Table I. A summary of the relevant clinical measurements for this cohort selection. Age in months, laterality of obstruction, grade of hydronephrosis by ultrasound (US), % function in each kidney, and t1/2 time on 99mTc mercaptoacetyltriglycine (MAG3) diuretic renogram are listed. A t1/2 is the measure of time it takes for of the radioisotope to be cleared from the kidney. A t1/2 > 20 minutes is considered to be pathologic for obstruction. UPJO patients selected for these studies all had significantly elevated t1/2 and persistent high grade hydronephrosis on serial US. Normal controls had no evidence of hydronephrosis. The patients studied were, based on current clinical parameters, unequivocally in need of surgical intervention.
| IEF STRIP | Sample | Gender | Age (mos) | Laterality | Hydronephrosis grade (0–4) | % Function R | % Function L | t1/2 MAG3 |
|---|---|---|---|---|---|---|---|---|
| B1,K1 | D1 | F | 6 | R | 4 | 46 | 54 | 54 |
| C1 | C1 | F | 1 | - | 0 | - | - | - |
| B2,K2 | D2 | M | 8 | L | 4 | 60 | 40 | 59 |
| C2 | C2 | M | 8 | - | 0 | - | - | - |
| B3,K3 | D3 | F | 7 | L | 4 | 50 | 50 | 100 |
| C3 | C3 | F | 11 | - | 0 | - | - | - |
| B4,K4 | D4 | M | 9 | R | 4 | 51 | 49 | 100 |
| C4 | C4 | M | 9 | - | 0 | - | - | - |
| B5,K5 | D5 | M | 3 | R | 4 | 53 | 47 | 100 |
| C5 | C5 | M | 5 | - | 0 | - | - | - |
| B6,K6 | D6 | M | 16 | L | 4 | 72 | 28 | 74 |
| C6 | C6 | M | 8 | - | 0 | - | - | - |
| B7,K7 | D7 | M | 10 | L | 4 | 51 | 49 | 68 |
| C7 | C7 | M | 10 | - | 0 | - | - | - |
| B8,K8 | D8 | M | 4 | R | 4 | 48 | 52 | 57 |
| C8 | C8 | M | 5 | - | 0 | - | - | - |