Table II. Candidate biomarkers of myocardial injury: known functions and potential clinical relevance in myocardial ischemia.

Accession No.	Protein description	Proteomics fold change	P value	Mean AUC (MI)	Mean AUC (NMI)	SE of difference	Clincal relevance
P02656	Apolipoprotein C-III	2.633	0.029	1.013E+08	4.037E+07	1.819E+07	Promotes development of hyperglyceridemia; atherogenic
P05090	Apolipoprotein D	1.860	0.033	6.877E+06	3.397E+06	1.088E+06	Compensatory response to dyslipidemia after myocardial injury
P02745	Complement C1q subcomponent subunit A	3.229	0.012	1.710E+07	5.457E+06	2.637E+06	Promotes post-infarct inflammation; aggravates myocardial injury
P01031	Complement C5	1.269	0.087	2.307E+07	1.713E+07	2.625E+06	Promotes post-infarct inflammation; aggravates myocardial injury
P07359	Platelet glycoprotein Ib alpha chain	9.181	< 0.0001	6.050E+06	5.587E+05	1.003E+05	Possible indicator of plaque rupture and/or thrombosis
P02775	Platelet basic protein	4.725	0.027	5.680E+06	1.460E+06	1.240E+06	Immune activation; possible indicator of vascular inflammation

AUC; Area under curve; CAD, Coronary artery disease; LDL, Low-density lipoprotein, HDL, High-density lipoprotein; SE: Standard error; MI, Myocardial infarction; NMI, Stable angina. Parametric student's t test analyses were performed using ion intensities obtained from MIbiological replicate 01, MIbiological replicate 02, MIcombined replicates search, NMIbiological replicate 01, NMIbiological replicate 02 and NMIcombined replicates search (p < 0.05 was considered statistically significant).