Fig. 3.

Identification of a subtype of ATCC cell line cohort enriched for RNA processing function. A, Unsupervised hierarchical clustering of ATCC subtype 2 (pink bar) specific sites with high relative phosphorylation. B, The ATCC subtypes 2 specific sites with high phosphorylation were analyzed for protein-protein (blue lines) and kinase-substrate (green lines) interactions. Blue circles indicate phosphoproteins enriched in this subtype that are involved in mRNA processing, and purple circles those in the splicosome pathway. C, SF3B1 tyrosine phosphorylation at pTyr sites 70 and 84 were summated for each cell line, and then normalized by median centering (z score).