FIGURE 4.

The whole-exome sequencing of the parental and gene-corrected iPSCs. A, single nucleotide variations in iPSCs by exome sequencing. B, insertions or deletions in the gene-corrected iPSCs by exome sequencing. C, genomic representation demonstrates the difference in the number of parental and gene-corrected iPSCs. Blue boxes represent amplifications, and red boxes represent deletions with sizes varying by CNV coverage. D, Chromosome Analysis Suite (ChAS) 2.0 data browser representation of the only de novo microduplication of chromosome 20 in gene-corrected iPSCs compared with its parental cells.