FIGURE 11.

Hepatic LRP1 deficiency impairs lipophagy in fasting mice. Liver extracts prepared from hLrp1^+/+ (filled bars) and hLrp1^−/− (open bars) mice after a 24-h fast were subjected to Western blotting analysis of ER stress and autophagic markers as indicated. The inset shows representative images of the blots with α-tubulin (bottom bands in CHOP, ATF6, and p62 blots), phosphorylated and total IRE1, and phosphorylated and total PERK levels. The data are presented as mean ± S.E. (error bars) of two independent experiments, each performed with four mice in each group. *, significant difference from the hLrp1^+/+ group at p < 0.05.