FIGURE 9.

Tauroursodeoxycholate treatment improves viability but not lysosomal permeability of palmitate-treated hLrp1^−/− hepatocytes. Primary hepatocytes isolated from hLrp1^+/+ and hLrp1^−/− mice were plated on coverslips and then treated with or without tauroursodeoxycholate (TUDCA) during the 6-h incubation with palmitate. The percentage of viable cells (A), apoptotic cells (B), and cells displaying lysosomal membrane permeability (C) was determined as described in the legends to Figs. 6 and 7. The graphs show the mean ± S.E. (error bars) of data obtained by counting 200 cells in three separate experiments with two biological replicate cultures. *, significant difference from the hLrp1^+/+ group at p < 0.05.