FIGURE 2.

The levels of metals other than copper are unchanged in the subcellular fractions of control and YS cells. The values for manganese in nuclear extracts were variable (1.7–5.9 ng/mg protein for control cells and 3.8–11.7 ng/mg protein for YS cells) in contrast to other metals, which were measured in parallel using ICP-MS and yielded consistent values. Although there is an apparent trend to higher mean values in YS cells, the difference was not statistically significant. Mean ± S.D. from three independent experiments is shown.