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. 2016 Jul 27;7:12313. doi: 10.1038/ncomms12313

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Schematic diagram showing haematopoietic ANGPTL4 function in atherosclerosis. ANGPTL4 is induced in macrophages in response to lipoprotein loading. ANGPTL4 deficiency in macrophages results in increase in foam cell formation, inflammation and apoptosis of macrophages within atherosclerotic plaques. Concomitantly, ANGPTL4 deficiency in haematopoietic cells results in an increase in the frequency and survival of CMPs, and upon WD feeding results in an elevated level of circulating monocytes. Overall, ANGPTL4 deficiency in haematopoietic cells promotes massive atherosclerosis.