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. 2016 Aug 5;6:30732. doi: 10.1038/srep30732

Table 1. Characteristics osf studies included for the meta-analysis.

First author Year Ethnicity Study design Phenotype of Maternal Hypertension Sample size
Adjusted OR (95%CI) Factors adjustd Results of ROP with maternal hypertension NOS qualityanalysis
ROP No ROP
Purohit, D. M. 1985 USA Prospective cohort Toxemia 328 2697 N/A N/A Increased risk of retrolental fibroplasia 7
Holmström, G. 1996 Stockholm, Sweden Retrospective case-control Pre-eclampsia 81 121 N/A N/A Inconclusive 5
Maheshwari, R. 1996 New Delhi, India Prospective cohort Maternal pregnancy-induced hypertension 13 53 N/A N/A Inconclusive 8
Seiberth, V. 2000 Germany Retrospective case-control Maternal pre-eclampsia 145 257 N/A N/A Inconclusive 5
Gupta, V. P. 2004 New Delhi, India Prospective cohort Maternal hypertension 13 47 N/A N/A No association 8
Shah, V. A. 2005 Singapore Retrospective case-control Maternal pre-eclampsia 165 399 2.51 (1.32–4.7) Pulmonary haemorrhage, duration of mechanical ventilation, duration of CPAP, BW Predictive of ROP 6
Çetinkaya, M. 2009 Bursa, Turkey Prospective cohort Pre-eclampsia 10 74 N/A N/A No association 9
Zayed, M. A. 2010 North Carolina, USA Restrospective case-control Maternal gestational hypertension 322 4818 N/A N/A No association 6
Fortes Filho, J. B. 2011 Brazil Prospective cohort Maternal pre-eclampsia 97 227 0.406 (0.202–0.817) Gestational age (GA), antenatal steroid treatment, use of oxygen in mechanical ventilation, use of indomethacin, blood transfusion, vaginal delivery, small for gestational age (SGA) Lowers risk of ROP in very-low-birth-weight (VLBW) infants 8
Özkan, H. 2011 Bursa, Turkey Prospective cohort Maternal pre-eclampsia 109 276 1.78 (0.66–1.90) GA, birth weight (BW), duration of mechanical ventilation, duration of total oxygen Increased risk of ROP in premature infants 8
Yang, C. Y. 2011 Northern Taiwan Retrospective case-control Maternal pre-eclampsia 99 117 2.52 (1.32–4.7) Duration of mechanical ventilation and BW Predictive of ROP 5
Mehmet, S. 2011 Izmir, Turkey Prospective cohort Maternal pre-eclampsia 86 117 N/A N/A Inconclusive 8
Chen, Y. 2011 North and South China Prospective cohort Pre-eclampsia N/A N/A 8.26 (2.36–28.9) GA, BW, maternal supplemental oxygen adminstration, fetus number Inconclusive 9
Martinez-Cruz, C. F. 2012 Mexican City Prospective cohort Maternal pre-eclampsia 34 105 N/A N/A Not mentioned 7
Yu, X. D. 2012 USA Retrospective case-control Pre-eclampsia (PET) and gestational hypertension (HTN) 1053 24420 0.66 (0.50–0.87) GA, mode of delivery, number of fetuses, race, body-mass-index at delivery, BW, gender, blood transfusion, congenital anomalies and intraventricular haemorrhage (IVH) PET but not gestational HTN lowers risk of ROP in preterm births 9
Ggaliardi, L. 2013 Italy Prospective cohort Gestational hypertensive disorder N/A N/A 2 (1–4) Level of birth centre and GA Not mentioned 7
Huang, H. C. 2015 Taiwan Retrospective review Maternal pre-eclampsia 2785 2933 1 (0.84–1.20) GA, BW, Cesarean section, sex, SGA, Apgar score at 5 min, RDS, transfusion, PDA, sepsis No assosciation in VLBW infants 8
Yau, G. S. K. 2016 Hong Kong Retrospective review Pre-eclampsia N/A N/A 0.26 (0.08–0.76) GA, BW, gestational diabetes mellitus, in-vitro fertilization, postnatal hypotension, inotrope use, bronchopulmonary dysplasia (BPD), surfactant use, invasive mechanical ventilation, mean oxygen concentration, patent ductus arteriosus (PDA), NSAID use, anemia, blood transfusion, IVH, hypoglycemia Protective 9
Gebeşçe, A. 2016 Istanbul, Turkey Retrospective review Maternal pre-eclampsia 48 162 3.200 (1.002–11.535) BW, respiratory distress syndrome (RDS), ventilator treatment, BPD Increased risk 7

N/A: not available.