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. 2016 Jun 28;8(7):180. doi: 10.3390/v8070180

Table 3.

Virus families that modulate PBs.

Genome Virus Family Virus PB Induction PB Blockade Mechanism Reference
I dsDNA Adenoviridae Adenovirus No Yes Decreased PB by redistribution of E4 11K [237]
Papillomaviridae Human papilloma virus (HPV) Yes * No Re-colocalization of PKR in PBs [46]
Herpesviridae Cytomegalovirus (HCMV) Yes No Increased of Dcp1a, EDC4, Rck/p54/DDX6 and Rap55 protein levels [238]
III dsRNA Reoviridae Rotavirus No Yes Decrease of XRN1, DCP1 and Pan3, but not GW182 protein levels [239]
IV (+)ssRNA Flaviviridae West Nile virus (WNV) No Yes Captures of Lsm1, GW182, DDX6, DDX3 and Xrn1 to viral replication factories (RF) [168,240]
Dengue virus (DENV) No Yes Captures of Lsm1, GW182, DDX6, DDX3 and Xrn1 to viral replication factories (RF) [168,240]
Yellow fever virus (YFV) Yes * No sfRNA stalls Xrn1 and co-localizes at PB [241]
Kunjin virus (KUNV), Australian strain of DENV Yes * No sfRNA stalls Xrn1 and co-localizes at PB [242]
Hepatitis C virus (HCV) Yes * Yes DDX6, Lsm1, Xrn1, PATL1 and Ago2 localize to lipid droplets [181]
Dcp2 not localize to viral factories [181]
Picornaviridae Poliovirus (PV) No Yes Cleavage of Xrn1, Dcp1a and Pan3 [248]
Protease 2A blocks PB formation [149]
Coxsackievirus B3 (CVB3) No Yes Cleavage of Xrn1, Dcp1a and Pan3 [248]
Dicistroviridae Cricket paralysis virus (CrPV) Yes Yes Disrupts only GW182/Dcp1 aggregate, but not Ago1/Ago2 [183]
Togaviridae Sindbis virus (SINV) No Yes HuR-translocation out of the nucleus [249]
V (-)ssRNA Orthomyxoviridae Influenza virus A (IAV) No Yes Interaction of RAP55 and NSP1 [190]
Bunyaviridae Hanta virus Yes * No Cap snatching occurs in PBs [204]
VI ssRNA-RT Retroviridae Human immunodeficiency virus type 1 (HIV-1) nd Yes HIV-1 mRNA interacts with DDX6, Ago 2 and APOBE3G and displaces from the PB [253]
Relocalization of PB during the HIV-1 infection [228]
Assembly intermediates (AIs) recruits DDX6 and ABCE1 [256]
Overexpression of MOV10 inhibits HIV-1 replication [258]

*maintains PB endogenously; nd = not determined; dsDNA = double-stranded DNA; dsRNA = double-stranded RNA; UPR = unfolded protein response; (+)ssRNA = positive-sense single strand RNA; (-)ssRNA = negative-sense single stand RNA; ssRNA-RT = single strand RNA retroviruses.