Table 1.

NDV-vectored vaccines against human pathogens.

Pathogen	Disease	Antigen	NDV Strain	Animal Model	Route of Inoculation *	Dose	Ref.
Influenza A H1N1	Respiratory	HA	B1	Mouse	iv, ip	3 × 107 PFU; two doses	[13]
HPAIV H5N1	Respiratory	HA	LaSota	African green monkey	in	2 × 107 PFU; two doses	[21]
HPIV3	Respiratory	HN	LaSota BC	African green and rhesus monkeys	in, it	106.5 PFU; two doses	[17]
EBOV	Hemorrhagic fever	GP	LaSota	Rhesus monkeys	in, it	Two doses	[19]
SARS-CoV	Respiratory	S	LaSota	African green monkeys	in, it	Two doses	[20]
SIV	simian AIDS	Gag	B1	Mouse	iv, ip, in	5 × 107 PFU; one or two doses	[27]
HIV	AIDS	Gag	B1	Mouse	in	5 × 105 PFU; two doses	[14]
HIV	AIDS	Env	LaSota	Guinea pig	in, im	106 PFU; two or three doses	[28]
HIV	AIDS	Env Gag	LaSota	Guinea pig	in	106 PFU; two or three doses	[29]
HIV	AIDS	Env (gp160, gp120)	LaSota	Guinea pig	in	106 PFU; three doses	[30]
HRSV	Respiratory	F	B1	Mouse	in	105.5 PFU; one dose	[31]
NiV	Encephalitis	F/G	LaSota	Mouse Pig	im	109 EID50; two doses	[32]
Borrelia burgdorferi	Lyme	BmpA OspC	LaSota	Hamster	in, im, ip	106 PFU	[33]
NoV	Gastroenteritis	VP1	LaSota BC	Mouse	in	106 EID50; two doses	[25]

* im: intramuscular, in: intranasal, ip: intraperitoneal, it: intratracheal, iv: intravenous, EID₅₀: 50% embryo infective dose.