Figure 5.

TNNT2‐MO treatment does not result in aberrant myofibrillogenesis. (A) An example of non‐treated cardiomyocytes in culture. Sarcomere assembly was categorized into four types: type 1 is the immature myofibril which is assembling at the periphery of the cell and no fibril structures can be seen (a); type 2 is when fibres are present but in a disorganized fashion (b); type 3 has organized but still thin fibrils (c); type 4 has fully developed thick fibrils running from one end of the cell to the other (d). Arrows indicate the direction of the myofilaments. Scale bar: 80 μm. (B) TNNT2‐MO treatment does not appear to affect sarcomere assembly and maturity (P > 0.180).