Table 3.
Comparison of ABO-incompatible adult living donor liver transplantation recipients between ischemic-type biliary lesion group and non-ischemic-type biliary lesion group
| ITBL group (n = 4) | non-ITBL group (n = 23) | P value | |
| Preoperative characteristics | |||
| Recipient age (yr) | 51 (47-53) | 49 (31- 65) | 0.721 |
| Recipient sex (M/F) | 3/1 | 18/5 | 1.000 |
| Donor age (yr) | 22 (21-37) | 24 (18-53) | 0.545 |
| Donor BMI | 21.6 ± 2.5 | 22.8 ± 3.2 | 0.495 |
| Blood type-A barrier | 3 (75%) | 17 (73.9%) | 1.000 |
| MELD | 13 (9-25) | 10 (6-34) | 0.567 |
| CTP score | 7 (5-11) | 5 (5-12) | 0.322 |
| Initial isoagglutinin titer | |||
| IgG (≥ 1:64) | 2 (50%) | 10 (43.5%) | 1.000 |
| IgM (≥ 1:64) | 2 (50%) | 9 (39.1%) | 1.000 |
| No. of PE (preoperative) | 2.5 (0-5) | 2 (0-15) | 0.802 |
| Initial B-cell (%) | 17.7 ± 3.7 | 16.2 ± 1.5 | 0.945 |
| Operative outcomes | |||
| Operation time (min) | 678.3 ± 28.8 | 645.6 ± 90.8 | 0.336 |
| Actual graft weight (g) | 585.5 ± 135.6 | 682.3 ± 105.9 | 0.117 |
| Actual GRWR (%) | 0.87 ± 0.29 | 0.99 ± 0.24 | 0.373 |
| Cold ischemic time (min) | 149.3 ± 28.7 | 114.4 ± 53.3 | 0.219 |
| Warm ischemic time (min) | 48.7 ± 11.8 | 45.8 ± 12.3 | 0.659 |
| Intra-operative transfusion (unit) | |||
| RBC | 1.7 ± 1.5 | 2.9 ± 3.9 | 0.572 |
| FFP | 1.7 ± 2.1 | 2.3 ± 2.7 | 0.678 |
| P-conc. | 2.0 ± 4.0 | 7.1 ± 6.7 | 0.159 |
| HAIT | 1 (25%) | 5 (21.7%) | 1.000 |
| Postoperative outcomes | |||
| Peak level of AST (IU/L) | 330.2 ± 240.7 | 223.5 ± 151.3 | 0.258 |
| Peak level of ALT (IU/L) | 435.0 ± 444.5 | 323.0 ± 230.5 | 0.462 |
| Peak level of total bilirubin (mg/dL) | 5.5 ± 2.2 | 3.9 ± 1.4 | 0.071 |
| Peak isoagglutinin titer | |||
| IgG (≥ 1:64) | 2 (50%) | 4 (17.4%) | 0.204 |
| IgM (≥ 1:64) | 1 (25%) | 3 (13.1%) | 0.279 |
| No. of PE (postoperative) | 2 (0-4) | 0 (0-6) | 0.090 |
| Post-operative transfusion (unit) | |||
| RBC | 2.3 ± 2.6 | 2.8 ± 4.2 | 0.811 |
| FFP | 0.5 ± 1.0 | 4.8 ± 7.5 | 0.264 |
| P-conc. | 9.0 ± 2.0 | 11.5 ± 13.7 | 0.721 |
| Post-LT ICU stay (d) | 4 (1-5) | 4 (3-6) | 0.900 |
| Post-LT hospital stay (d) | 39 (28-51) | 28 (20-75) | 0.277 |
| BPACR | 1 (25%) | 5 (21.7%) | 1.000 |
| BPAMR | 1 (25%) | 0 | 0.148 |
| Complications | |||
| Post-LT hemorrhage | 0 | 4 (17.4%) | 1.000 |
| CMV infection | 0 | 7 (30.4%) | 0.545 |
| Bacterial infection | 0 | 1 (4.3%) | 1.000 |
| B-cell follicle score in spleen | 3.7 ± 0.5 | 2.6 ± 1.1 | 0.067 |
| Plasma cell count in spleen | 73.0 ± 19.0 | 76.8 ± 47.9 | 0.878 |
ABO-I ALDLT: ABO-incompatible adult living donor liver transplantation; ITBL: Ischemic-type biliary lesion; BMI: Body mass index; MELD: Model for end-stage liver disease; CTP: Child-Turcotte-Pugh; PE: Plasma exchange; GRWR: Graft-to-recipient weight ratio; RBC: Red blood cell; FFP: Fresh frozen plasma; P-conc.: Platelet concentrate; HAIT: Hepatic artery infusion therapy; AST: Aspartate transaminase; ALT: Alanine transaminase; LT: Liver transplantation; ICU: Intensive care unit; BPACR: Biopsy-proven acute cellular rejection; BPAMR: Biopsy-proven antibody-mediated rejection; CMV: Cytomegalovirus.