Table 1. Canonical pathways differentially expressed in ameloblastoma clusters.
| Canonical pathways different between the ameloblastoma common tumor cluster and normal cells | ||||
|---|---|---|---|---|
| Biological process | Ingenuity Canonical Pathways | −log(p-value*) | Ratio | z-score |
| Inflammatory (Immune) response/cytokine signaling | fMLP Signaling in Neutrophils | 4.81 | 0.28 | 3.674 |
| CXCR4 Signaling | 2.68 | 0.21 | 1.961 | |
| TREM1 Signaling | 2.34 | 0.25 | −1.213 | |
| Thrombin Signaling | 2.21 | 0.19 | 1.512 | |
| Acute Phase Response Signaling | 2.20 | 0.20 | 2.117 | |
| IL-8 Signaling | 2.12 | 0.19 | 2.785 | |
| Complement System | 1.94 | 0.28 | −1.89 | |
| Cell cycle regulation | Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 4.23 | 0.35 | −1.069 |
| Role of BRCA1 in DNA Damage Response | 2.88 | 0.26 | 1.941 | |
| Cell Cycle: G1/S Checkpoint Regulation | 1.63 | 0.22 | −1.155 | |
| Cyclins and Cell Cycle Regulation | 1.53 | 0.21 | 1.941 | |
| Cancer | Colorectal Cancer Metastasis Signaling | 2.04 | 0.18 | 1 |
| Pancreatic Adenocarcinoma Signaling | 1.63 | 0.20 | 1.291 | |
| Glioblastoma Multiforme Signaling | 1.40 | 0.18 | 2.132 | |
| Wnt/β-catenin Signaling | 1.37 | 0.18 | 1.528 | |
| Actin Nucleation by ARP-WASP Complex | 1.35 | 0.21 | 2.111 | |
| Map kinase related | Gαq Signaling | 3.31 | 0.23 | 2.117 |
| α-Adrenergic Signaling | 2.77 | 0.25 | 1.069 | |
| Phospholipase C Signaling | 1.83 | 0.18 | 1.461 | |
| Prolactin Signaling | 1.74 | 0.22 | 3.051 | |
| Receptor tyrosine kinase (RTK) | Ephrin B Signaling | 4.21 | 0.30 | −1.155 |
| Neuregulin Signaling | 1.69 | 0.21 | 2.668 | |
| Nuclear receptor signaling | Androgen Signaling | 2.01 | 0.21 | 2.333 |
| Cellular growth and proliferation | Growth Hormone Signaling | 1.32 | 0.20 | 1.941 |
| Others | Cardiac β-adrenergic Signaling | 1.87 | 0.20 | 2.138 |
| Role of NFAT in Cardiac Hypertrophy | 1.47 | 0.18 | 1.961 | |
| Canonical pathways different for the ameloblastoma presecretory cluster | ||||
| Inflammatory (Immune) response/cytokine signaling | Acute Phase Response Signaling | 12.20 | 0.23 | 1.225 |
| Production of Nitric Oxide and Reactive Oxygen Species in Macrophages | 4.26 | 0.15 | 3.138 | |
| Extrinsic Prothrombin Activation Pathway | 3.55 | 0.38 | 1.633 | |
| Leukocyte Extravasation Signaling | 2.63 | 0.12 | 2.324 | |
| Role of NFAT in Regulation of the Immune Response | 2.08 | 0.11 | 3 | |
| IL-8 Signaling | 1.95 | 0.11 | 1.886 | |
| iCOS-iCOSL Signaling in T Helper Cells | 1.91 | 0.13 | 2.333 | |
| Antioxidant Action of Vitamin C | 1.80 | 0.13 | −1.897 | |
| CD28 Signaling in T Helper Cells | 1.60 | 0.12 | 2.333 | |
| TREM1 Signaling | 1.55 | 0.13 | 1.667 | |
| Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 1.44 | 0.11 | 1.897 | |
| eNOS Signaling | 1.35 | 0.10 | 1.604 | |
| Cellular growth and proliferation | Growth Hormone Signaling | 2.44 | 0.16 | 1.897 |
| p70S6K Signaling | 2.15 | 0.13 | 2.138 | |
| Mouse Embryonic Stem Cell Pluripotency | 1.84 | 0.13 | 3.464 | |
| Oncostatin M Signaling | 1.75 | 0.18 | 2.236 | |
| VEGF Signaling | 1.63 | 0.12 | 2.121 | |
| Protein tyrosine kinase (PTK) | Tec Kinase Signaling | 1.73 | 0.11 | 1.387 |
| Cancer | Colorectal Cancer Metastasis Signaling | 1.71 | 0.10 | 1.706 |
| Wnt/Ca+ pathway | 1.68 | 0.15 | 1.89 | |
| Others | Melatonin Signaling | 1.59 | 0.13 | 1.414 |
| Endothelin-1 Signaling | 1.45 | 0.10 | 2 | |
| Prolactin Signaling | 1.41 | 0.12 | 2.121 | |
| Canonical pathways different for the ameloblastoma odontoblast cluster | ||||
| Inflammatory (Immune) response/cytokine signaling | Leukocyte Extravasation Signaling | 3.99 | 0.16 | −2.524 |
| Acute Phase Response Signaling | 3.51 | 0.16 | 1.897 | |
| Extrinsic Prothrombin Activation Pathway | 2.30 | 0.31 | −1.342 | |
| TREM1 Signaling | 1.89 | 0.16 | −1.508 | |
| Complement System | 1.80 | 0.19 | −1 | |
| Production of Nitric Oxide and Reactive Oxygen Species in Macrophages | 1.33 | 0.11 | −2.236 | |
| Nuclear receptor signaling | LXR/RXR Activation | 5.57 | 0.21 | −1.225 |
| Cancer | Colorectal Cancer Metastasis Signaling | 2.67 | 0.13 | −3.157 |
| Cellular growth and proliferation | Mouse Embryonic Stem Cell Pluripotency | 2.01 | 0.15 | −3.207 |
*p-value < 0.05.