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. Author manuscript; available in PMC: 2016 Aug 5.
Published in final edited form as: Biochemistry. 2016 Apr 20;55(17):2452–2464. doi: 10.1021/acs.biochem.5b01373

Figure 7. A model for the function of reversible GSNOR nitrosation.

Figure 7

A: During a nitric oxide burst, GSNOR is nitrosated on conserved cysteines, leading to a decrease in enzymatic activity. Lower GSNOR activity facilitates accumulation of GSNO, itself an agent of protein nitrosation. By allowing GSNO to accumulate, down-regulation of GSNOR permits robust nitric oxide signaling. B: Eventually GSNOR is re-reduced by cellular antioxidant machinery, whereupon GSNO concentrations are returned to basal levels by GSNOR.