Table 4.
χ2 | HR (95% CI) | P-value | |
---|---|---|---|
Geographic region (reference = Canada/US) | |||
Latin America | 108.70 | 0.53 (0.44, 0.64) | <0.0001 |
Eastern Europe | 0.64 (0.56, 0.74) | ||
Western Europe | 1.05 (0.91, 1.20) | ||
East Asia | 1.04 (0.89, 1.21) | ||
COPD | 35.94 | 1.46 (1.29, 1.66) | <0.0001 |
Baseline diuretic use | 35.91 | 1.36 (1.23, 1.51) | <0.0001 |
Creatinine clearance, per 5-unit decrease below 65a | 25.90 | 1.07 (1.04, 1.10) | <0.0001 |
SBP, per 5-mmHg decrease below 120b | 18.21 | 1.08 (1.04, 1.13) | <0.0001 |
Diabetes | 17.38 | 1.22 (1.11, 1.34) | <0.0001 |
Prior myocardial infarction | 16.91 | 1.27 (1.13, 1.42) | <0.0001 |
Prior aspirin use | 12.39 | 1.21 (1.09, 1.34) | 0.0004 |
BMI, per 1 unit increase above 31c | 9.79 | 1.02 (1.01, 1.03) | 0.0018 |
Age, per 5 year increase | 8.78 | 1.05 (1.02, 1.08) | 0.0030 |
Prior use of vitamin K antagonist | 7.43 | 1.18 (1.05, 1.32) | 0.0064 |
Male | 6.14 | 1.13 (1.03, 1.25) | 0.013 |
Carotid artery disease | 5.38 | 1.25 (1.04, 1.51) | 0.020 |
Heart rate, per 5 bpm increase above 90d | 4.82 | 1.04 (1.00, 1.08) | 0.028 |
BMI, body mass index; SBP, systolic blood pressure; US, United States.
aFor creatinine clearance, there was equivalent risk for all values ≥65 mL/min.
bFor SBP, there was equivalent risk for all values ≥120 mmHg.
cFor BMI, there was equivalent risk for all values ≤31 kg/m2.
dFor heart rate, there was equivalent risk for all values ≤90 beats per minute.