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. 2016 Aug 1;7:12348. doi: 10.1038/ncomms12348

Figure 4. Gene expression profiling of cutaneous wound healing in mice.

Figure 4

Full-thickness skin resected around the areas of the initial wound was analysed for gene expression profiling by RNASeq. Top, Expression, regulation and overall enrichment of BRAF signature genes as measurement of MAPK pathway activity. Bottom, expression changes and enrichment of wound-healing signature genes (GO: 0042060). There is enrichment of the BRAF signature at day 2 and 6 in vemurafenib-treated wounds, with a significant increase of the wound-healing signature at day 6. Enrichment scores, GSVA (the scores are normally distributed around 0 where negative values indicate relative de-enrichment of the signature and positive values indicate enrichment).