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. 2016 Aug 1;7:12348. doi: 10.1038/ncomms12348

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Copyright © 2016, The Author(s)

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(a) Representative photomicrograph immunohistochemistry images of PECAM-1+ cells in an excisional wound splinting model of mice treated with vehicle or vemurafenib on day 6 post-treatment and bar graph, on the right side, representing the quantification of PECAM-1+ cells on the vehicle- and vemurafenib-treated wounds on day 6 (P=0.006 by t-test; n=4). Wound area indicated with an arrow. (b) Representative photomicrograph immunohistochemistry images of PECAM-1+ cells in an incisional wound model of mice treated with vehicle, vemurafenib (VEM), trametinib (TRAME) or the combination (VEM+TRAME); (P=0.0002 by one-way ANOVA). Trametinib alone completely depleted the number of PECAM-1+ cells. Wound area between double head arrows. Error bars, mean±s.d. Bar graphs represent one experiment with 4 replicates per group.