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. 2016 Aug 1;7:12348. doi: 10.1038/ncomms12348

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Copyright © 2016, The Author(s)

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(a) Representative images of mice from each study group on week 15 of treatment. Topical application of 7,12-Dimethylbenz[a]anthracene (DMBA) to FvB/N mice followed by 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin papillomas and squamous cell carcinomas by week 8 of treatment. In the control (DMBA+TPA) group all eight mice developed tumours. In the groups with DMBA or acetone control, followed by topical application of vemurafenib (VEM, 2 or 4 mg per mice) no skin tumours were induced. (b) Graph representations of tumour count and percentage of tumour incidence per week. Error bars in b, mean±s.d.; n=8.