Table II.
Significant networks identified by pathway analysis in spontaneous premature ovarian failure (POF) patients.
| Term ID | Term name | Level | Adjusted P-valuea |
|---|---|---|---|
| GO:0048247 | Lymphocyte chemotaxis | 1 | 2.83 × 10−2 |
| GO:0002548 | Monocyte chemotaxis | 1 | 8.49 × 10−3 |
| GO:0072677 | Eosinophil migration | 1 | 4.96 × 10−5 |
| GO:0048245 | Eosinophil chemotaxis | 1.1 | 7.68 × 10−6 |
| KEGG:04062 | Chemokine signaling pathway | 1 | 4.11 × 10−2 |
| REAC:168249 | Innate immune system | 1 | 2.11 × 10−3 |
| REAC:2454202 | Fc epsilon receptor (FCERI) signaling | 1.1 | 5.76 × 10−7 |
| REAC:2029480 | Fc gamma receptor (FCGR) dependent phagocytosis | 1.2 | 2.00 × 10−19 |
| REAC:166658 | Complement cascade | 1.3 | 2.41 × 10−27 |
| REAC:5653656 | Vesicle-mediated transport | 1 | 5.80 × 10−10 |
| REAC:2173782 | Binding and uptake of ligands by scavenger receptors | 1.1 | 3.68 × 10−23 |
| REAC:2168880 | Scavenging of heme from plasma | 1.1.1 | 2.41 × 10−30 |
| REAC:1280218 | Adaptive immune system | 1 | 7.48 × 10−5 |
| REAC:198933 | Immunoregulatory interactions between a lymphoid and a nonlymphoid cell | 1.1 | 2.05 × 10−15 |
Functional enrichment analysis of genes within rearranged regions was performed using the web-based g:Profiler software. Gene Ontology (GO), KEGG pathway and Reactome (REAC) datasets with adjusted P-value < 0.05 were considered to be statistically significant.
aMultiple testing corrected enrichment P-value.