Fig. 11.

Higher SMARCE1 and PTK2 expression is associated with poor prognosis of breast cancer patients. a Kaplan-Meier analysis of recurrence-free survival (RFS) of breast cancer patients based on SMARCE1 and PTK2 expression using a dataset of 3554 breast tumor samples (http://kmplot.com/analysis/). To construct Kaplan-Meier curves all percentiles between the lower and upper quartiles were computed and the best performing threshold was used as cutoff to divide the patient cohort. The log-rank test p value was calculated by using RFS up to 15 years as end point. b Correlated expression of SMARCE1 and PTK2 in basal-like and luminal B subtypes of breast cancer according to the TCGA database. Tumors with PTK2 amplification were excluded from the correlation analysis. c Frequency of genetic alterations of SWI/SNF complex subunits in breast tumors according to the TCGA database