Table 3.

Performance of feet-ESC to detect diabetic peripheral neuropathy and the RFU against traditional tests

	Feet-ESC < 50μS
	Sensitivity	Specificity	AUC	PPV	NPV	+LH	-LH
DPN:VPT ≥ 25v	90.1	77	0.841	13	99	3.98	0.12
DPN:NDS ≥ 3	61.2	85.2	0.732	54	85	4.12	0.46
RFU:NDS ≥ 6	63.8	81.9	0.729	40	92	3.53	0.44
Confirmed-DPN	38.4	91	0.648	85.7	52	4.3	0.67
	Feet-ESC <70μS
DPN:VPT ≥ 25v	100	46	0.732	6.7	100	1.86	0
DPN:NDS ≥ 3	80.6	51	0.663	32.5	90	1.66	0.38
RFU:NDS ≥ 6	80.9	49	0.651	23	93	1.59	0.39
Confirmed-DPN	67.2	58.9	0.63	93	56	1.6	0.56

DPN diabetic peripheral neuropathy. RFU risk of foot ulceration. ESC electrochemical skin conductance. VPT vibration perception threshold. NDS neuropathy disability score. AUC area under the curve. PPV positive predictive value. NPV negative predictive value. +LH positive likelihood. –LH negative likelihood