Table 3.
Antipyretic activity of Monotheca buxifolia hydro-ethanolic extract (MBHE) in brewer’s yeast induced pyrexia in mice
| Treatment | 1st h | 2nd h | 3rd h | 4th h | 5th h |
|---|---|---|---|---|---|
| Group 1 (Brewer’s yeast + Saline) |
100.4 ± 0.358 | 100.5 ± 0.346 | 100.0 ± 0.335 | 100.4 ± 0.265 | 100.5 ± 0.341 |
| Group 2 (Acetaminophen 150 mg/kg) |
96.18 ± 0.757*** | 96.62 ± 0.755*** | 95.50 ± 1.023*** | 96.07 ± 0.720*** | 95.23 ± 0.731*** |
| Group 3 (MBHE 50 mg/kg) |
97.93 ± 0.449 | 98.20 ± 0.634* | 98.58 ± 0.838 | 99.27 ± 0.860 | 99.88 ± 0.812 |
| Group 4 (MBHE 100 mg/kg) |
96.02 ± 0.884*** | 97.18 ± 0.570** | 97.68 ± 0.244* | 97.72 ± 0.342* | 97.42 ± 0.709* |
| Group 5 (MBHE 150 mg/kg) |
93.70 ± 0.753*** | 96.93 ± 0.584*** | 96.48 ± 0.303** | 97.33 ± 0.547** | 96.35 ± 0.837** |
Values are expressed as mean rectal temperature in °F ± SD. ANOVA followed by Dunnett’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001 compared to group 1. n = 6 animals per group