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. 2016 Aug 5;17:30. doi: 10.1186/s12860-016-0108-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Example of evaluation of copy number by ddPCR. Panel a shows an annotated example of FACS-like plot obtained with the QuantaSoft software, version 1.2.10.0 (Bio-Rad, CA, USA) taken from a CNV2 copy counting ddPCR experiment. Panel b and c show typical results obtained from quantifying Chr 8 in a euploid and a trisomic sample, respectively. Panel d shows copy numbers as calculated and presented in the CNV option obtained with known euploid (Normal) and trisomic for Chr 1, 8 and 11 (Trisomic) samples as external calibrators. A new sample of unknown quality is shown to be injectable. Vertical bars are Standard Errors. Panel e presents the distribution of the marker genes and their mouse chromosomal location and the assays that were employed in this study (* and ** show the position on Chr 8 of Tlr3 and Gse1, respectively)