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. 2016 Aug 5;16:125. doi: 10.1186/s12883-016-0650-z

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Graphic illustration of the CPM effect’s calculation. a Whisker plots of the mean of three pain ratings for TS_before and TS_during, resulting in the early CPM-effect. b Whisker plots of the mean of three pain ratings for TS_before and TS_after, resulting in the late CPM-effect. The bottom and the top of the boxes represent the first and third quartiles, the band inside is the median. The ends of the whiskers illustrate the maximum and minimum. TS were applied before, during and after the conditioning stimulus. CPM, conditioned pain modulation; NRS, numeric rating scale; TS, test stimulus