Table 3.
Hypothetical sample size calculations for crossover and parallel designs in terms of successful treatment
| Patients return to normal CPM effect (rate of treatment success) | Early CPM effect | Late CPM effect | ||
|---|---|---|---|---|
| Crossover | Parallel | Crossover | Parallel | |
| 100 % | 6 | 18 | 45 | 176 |
| 75 % | 10 | 34 | 122 | 484 |
| 50 % | 18 | 68 | 272 | 542 |
| 25 % | 84 | 330 | 1084 | 4332 |
CPM Conditioned Pain Modulation. Calculations are based on the question how many subjects are needed to treat to elevate “non responders” to “normal responders” in case of 25/ 50/ 75/ 100 % treatment success. All values are given as the number of subjects for each group