Table 3.
Association Results in the Discovery and Replication Samples for the SNPs Shown in Table 2
| SNP |
P Value for Replication Cohort
|
P Value for Meta-analysis
|
Directiond | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Yale-Penn 3 Cohorta
|
ICGHD Cohort | Discovery Cohortb
|
Discovery + Replication Cohortc
|
All Participants | |||||
| African American | European American | African American | European American | African American | European American | ||||
| rs74823926 | 9.40 × 10−3 | 7.54 × 10−1 | 6.36 × 10−2 | 5.26 × 10−7 | 6.36 × 10−1 | 3.34 × 10−6 | 1.59 × 10−1 | 8.62 × 10−6 | +x++++−++ |
|
| |||||||||
| rs114383460 | 7.22 × 10−1 | NA | NA | 1.09 × 10−6 | NA | 1.93 × 10−6 | NA | 1.93 × 10−6 | +x + xxx−xx |
|
| |||||||||
| rs12621150 | 9.68 × 10−1 | 1.15 × 10−1 | 3.61 × 10−1 | 7.67 × 10−1 | 1.05 × 10−6 | 7.75 × 10−1 | 7.92 × 10−6 | 5.13 × 10−4 | ++++−+−−+ |
|
| |||||||||
| rs7586604 | 2.80 × 10−1 | 2.78 × 10−1 | 6.04 × 10−1 | 4.15 × 10−5 | 6.19 × 10−3 | 1.76 × 10−5 | 1.69 × 10−2 | 1.81 × 10−6 | −−−−−−−+− |
|
| |||||||||
| rs144605126 | 1.18 × 10−1 | NA | NA | 8.67 × 10−7 | NA | 3.84 × 10−6 | NA | 3.84 × 10−6 | +x + x + x−xx |
|
| |||||||||
| rs150064803 | 1.74 × 10−1 | NA | NA | 3.41 × 10−7 | NA | 1.41 × 10−6 | NA | 1.41 × 10−6 | +x + x + x−xx |
|
| |||||||||
| rs143020225 | 1.53 × 10−1 | NA | NA | 7.19 × 10−7 | NA | 1.95 × 10−7 | NA | 1.95 × 10−7 | +x + xxx + xx |
|
| |||||||||
| rs143244591 | 3.24 × 10−3 | NA | NA | 2.18 × 10−8e | NA | 4.32 × 10−10e | NA | 4.32 × 10−10e | +x + x + x+xx |
|
| |||||||||
| rs73252553 | 6.40 × 10−1 | 8.32 × 10−2 | 4.10 × 10−1 | 1.18 × 10−3 | 2.28 × 10−5 | 2.25 × 10−3 | 5.45 × 10−6 | 5.57 × 10−8 | ++++++−++ |
|
| |||||||||
| rs28595532 | 8.06 × 10−1 | 6.07 × 10−2 | 2.24 × 10−1 | 2.02 × 10−7 | 1.08 × 10−1 | 1.89 × 10−7 | 1.52 × 10−1 | 3.60 × 10−6 | ++++++++− |
|
| |||||||||
| rs114311699 | 7.30 × 10−1 | NA | NA | 3.78 × 10−7 | NA | 2.75 × 10−7 | NA | 2.75 × 10−7 | +x + x + x+xx |
|
| |||||||||
| rs10066744 | 3.89 × 10−1 | NA | NA | 4.82 × 10−7 | NA | 2.27 × 10−7 | NA | 2.27 × 10−7 | +x + xxx + xx |
|
| |||||||||
| rs17665889 | 2.17 × 10−1 | 1.17 × 10−1 | 7.65 × 10−1 | 1.51 × 10−1 | 9.41 × 10−8 | 2.69 × 10−1 | 5.39 × 10−6 | 8.41 × 10−4 | −+++−++−+ |
|
| |||||||||
| rs12534830 | 5.85 × 10−1 | 8.67 × 10−1 | 3.99 × 10−1 | 7.76 × 10−3 | 1.54 × 10−5 | 1.05 × 10−2 | 3.40 × 10−5 | 1.12 × 10−6 | ++++++−−+ |
|
| |||||||||
| rs77378271 | 9.25 × 10−2 | 4.19 × 10−2f | 7.95 × 10−1 | 2.13 × 10−1 | 2.76 × 10−8e | 1.07 × 10−1 | 5.16 × 10−8 | 2.13 × 10−8e | +−++x+++− |
|
| |||||||||
| rs10969106 | NA | 5.50 × 10−1 | 8.47 × 10−1 | NA | 7.39 × 10−8 | NA | 1.74 × 10−7 | 1.74 × 10−7 | x + x + x+xx+ |
|
| |||||||||
| rs115553536 | 1.80 × 10−1 | NA | NA | 6.46 × 10−7 | NA | 2.14 × 10−6 | NA | 2.14 × 10−6 | +x + x + x−xx |
|
| |||||||||
| rs74400468 | 3.49 × 10−2 | 6.61 × 10−1 | 5.66 × 10−1 | 5.53 × 10−2 | 1.59 × 10−6 | 1.22 × 10−2 | 2.46 × 10−5 | 9.82 × 10−7 | ++−+++++− |
|
| |||||||||
| rs12218439 | 2.29 × 10−1 | 1.01 × 10−1 | 3.21 × 10−1 | 1.01 × 10−6 | 2.01 × 10−1 | 4.91 × 10−6 | 2.13 × 10−1 | 4.20 × 10−4 | x++−++−−+ |
|
| |||||||||
| rs146091982 | 8.84 × 10−4 | NA | NA | 1.95 × 10−7 | NA | 1.33 × 10−9e | NA | 1.33 × 10−9e | +x + x + x+xx |
|
| |||||||||
| rs73443003 | 2.53 × 10−2 | NA | NA | 1.31 × 10−6 | NA | 1.20 × 10−7 | NA | 1.20 × 10−7 | −x−x−x−xx |
|
| |||||||||
| rs200453611 | 7.29 × 10−1 | 5.20 × 10−1 | 9.40 × 10−1 | 9.43 × 10−7 | 6.24 × 10−1 | 1.56 × 10−6 | 5.34 × 10−1 | 1.12 × 10−3 | ++++++−++ |
|
| |||||||||
| rs200391037 | 9.28 × 10−1 | 3.09 × 10−2f | 4.19 × 10−1 | 1.02 × 10−1 | 3.72 × 10−6 | 1.04 × 10−1 | 4.32 × 10−5 | 1.10 × 10−5 | ++++++−−+ |
|
| |||||||||
| rs193047854 | 6.74 × 10−1 | NA | NA | 7.06 × 10−7 | NA | 5.51 × 10−7 | NA | 5.51 × 10−7 | +x + xxx + xx |
|
| |||||||||
| rs199783889 | 4.38 × 10−1 | NA | NA | 3.32 × 10−7 | NA | 1.12 × 10−6 | NA | 1.12 × 10−6 | +x + xxx−xx |
|
| |||||||||
| rs78068107 | 2.90 × 10−2 | NA | NA | 1.02 × 10−6 | NA | 1.31 × 10−5 | NA | 1.31 × 10−5 | +x + xxx−xx |
|
| |||||||||
| rs186825689 | 4.51 × 10−1 | NA | NA | 1.86 × 10−8e | NA | 8.27 × 10−8 | NA | 8.27 × 10−8 | +x + xxx−xx |
Abbreviations: ICGHD, International Consortium on the Genetics of Heroin Dependence; NA, not applicable; SAGE, Study of Addiction: Genetics and Environment; SNP, single-nucleotide polymorphism.
Indicates participants in the Yale-Penn cohort who did not undergo genotyping at the time of the discovery analyses.
Indicates participants in the Yale-Penn cohort (Yale-Penn 1 and 2) who underwent genotyping for the discovery analysis and in the SAGE cohort.
Indicates all cohorts.
For the effect direction, the order of the symbols is the Yale-Penn 1 African American cohort, Yale-Penn 1 European American cohort, SAGE African American cohort, SAGE European American cohort, Yale-Penn 2 African American cohort, Yale-Penn 2 European American cohort, Yale-Penn 3 African American cohort, Yale-Penn 3 European American cohort, and the ICGHD European American cohort. + Indicates effect allele (listed in Table 2) is associated with an increase in cannabis dependence (CAD) criterion count; −, effect allele is associated with a decrease in CAD criterion count; and x, a valid effect estimate could not be obtained. See the Statistical Analysis subsection of the Methods section for an explanation of Yale-Penn 1, 2, and 3.
Indicates genome-wide significant P values.
Indicates P < .05 in the replication sample.