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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: JAMA Psychiatry. 2016 May 1;73(5):472–480. doi: 10.1001/jamapsychiatry.2016.0036

Table 3.

Association Results in the Discovery and Replication Samples for the SNPs Shown in Table 2

SNP P Value for Replication Cohort
P Value for Meta-analysis
Directiond
Yale-Penn 3 Cohorta
ICGHD Cohort Discovery Cohortb
Discovery + Replication Cohortc
All Participants
African American European American African American European American African American European American
rs74823926 9.40 × 10−3 7.54 × 10−1 6.36 × 10−2 5.26 × 10−7 6.36 × 10−1 3.34 × 10−6 1.59 × 10−1 8.62 × 10−6 +x++++−++
rs114383460 7.22 × 10−1 NA NA 1.09 × 10−6 NA 1.93 × 10−6 NA 1.93 × 10−6 +x + xxx−xx
rs12621150 9.68 × 10−1 1.15 × 10−1 3.61 × 10−1 7.67 × 10−1 1.05 × 10−6 7.75 × 10−1 7.92 × 10−6 5.13 × 10−4 ++++−+−−+
rs7586604 2.80 × 10−1 2.78 × 10−1 6.04 × 10−1 4.15 × 10−5 6.19 × 10−3 1.76 × 10−5 1.69 × 10−2 1.81 × 10−6 −−−−−−−+−
rs144605126 1.18 × 10−1 NA NA 8.67 × 10−7 NA 3.84 × 10−6 NA 3.84 × 10−6 +x + x + x−xx
rs150064803 1.74 × 10−1 NA NA 3.41 × 10−7 NA 1.41 × 10−6 NA 1.41 × 10−6 +x + x + x−xx
rs143020225 1.53 × 10−1 NA NA 7.19 × 10−7 NA 1.95 × 10−7 NA 1.95 × 10−7 +x + xxx + xx
rs143244591 3.24 × 10−3 NA NA 2.18 × 10−8e NA 4.32 × 10−10e NA 4.32 × 10−10e +x + x + x+xx
rs73252553 6.40 × 10−1 8.32 × 10−2 4.10 × 10−1 1.18 × 10−3 2.28 × 10−5 2.25 × 10−3 5.45 × 10−6 5.57 × 10−8 ++++++−++
rs28595532 8.06 × 10−1 6.07 × 10−2 2.24 × 10−1 2.02 × 10−7 1.08 × 10−1 1.89 × 10−7 1.52 × 10−1 3.60 × 10−6 ++++++++−
rs114311699 7.30 × 10−1 NA NA 3.78 × 10−7 NA 2.75 × 10−7 NA 2.75 × 10−7 +x + x + x+xx
rs10066744 3.89 × 10−1 NA NA 4.82 × 10−7 NA 2.27 × 10−7 NA 2.27 × 10−7 +x + xxx + xx
rs17665889 2.17 × 10−1 1.17 × 10−1 7.65 × 10−1 1.51 × 10−1 9.41 × 10−8 2.69 × 10−1 5.39 × 10−6 8.41 × 10−4 −+++−++−+
rs12534830 5.85 × 10−1 8.67 × 10−1 3.99 × 10−1 7.76 × 10−3 1.54 × 10−5 1.05 × 10−2 3.40 × 10−5 1.12 × 10−6 ++++++−−+
rs77378271 9.25 × 10−2 4.19 × 10−2f 7.95 × 10−1 2.13 × 10−1 2.76 × 10−8e 1.07 × 10−1 5.16 × 10−8 2.13 × 10−8e +−++x+++−
rs10969106 NA 5.50 × 10−1 8.47 × 10−1 NA 7.39 × 10−8 NA 1.74 × 10−7 1.74 × 10−7 x + x + x+xx+
rs115553536 1.80 × 10−1 NA NA 6.46 × 10−7 NA 2.14 × 10−6 NA 2.14 × 10−6 +x + x + x−xx
rs74400468 3.49 × 10−2 6.61 × 10−1 5.66 × 10−1 5.53 × 10−2 1.59 × 10−6 1.22 × 10−2 2.46 × 10−5 9.82 × 10−7 ++−+++++−
rs12218439 2.29 × 10−1 1.01 × 10−1 3.21 × 10−1 1.01 × 10−6 2.01 × 10−1 4.91 × 10−6 2.13 × 10−1 4.20 × 10−4 x++−++−−+
rs146091982 8.84 × 10−4 NA NA 1.95 × 10−7 NA 1.33 × 10−9e NA 1.33 × 10−9e +x + x + x+xx
rs73443003 2.53 × 10−2 NA NA 1.31 × 10−6 NA 1.20 × 10−7 NA 1.20 × 10−7 −x−x−x−xx
rs200453611 7.29 × 10−1 5.20 × 10−1 9.40 × 10−1 9.43 × 10−7 6.24 × 10−1 1.56 × 10−6 5.34 × 10−1 1.12 × 10−3 ++++++−++
rs200391037 9.28 × 10−1 3.09 × 10−2f 4.19 × 10−1 1.02 × 10−1 3.72 × 10−6 1.04 × 10−1 4.32 × 10−5 1.10 × 10−5 ++++++−−+
rs193047854 6.74 × 10−1 NA NA 7.06 × 10−7 NA 5.51 × 10−7 NA 5.51 × 10−7 +x + xxx + xx
rs199783889 4.38 × 10−1 NA NA 3.32 × 10−7 NA 1.12 × 10−6 NA 1.12 × 10−6 +x + xxx−xx
rs78068107 2.90 × 10−2 NA NA 1.02 × 10−6 NA 1.31 × 10−5 NA 1.31 × 10−5 +x + xxx−xx
rs186825689 4.51 × 10−1 NA NA 1.86 × 10−8e NA 8.27 × 10−8 NA 8.27 × 10−8 +x + xxx−xx

Abbreviations: ICGHD, International Consortium on the Genetics of Heroin Dependence; NA, not applicable; SAGE, Study of Addiction: Genetics and Environment; SNP, single-nucleotide polymorphism.

a

Indicates participants in the Yale-Penn cohort who did not undergo genotyping at the time of the discovery analyses.

b

Indicates participants in the Yale-Penn cohort (Yale-Penn 1 and 2) who underwent genotyping for the discovery analysis and in the SAGE cohort.

c

Indicates all cohorts.

d

For the effect direction, the order of the symbols is the Yale-Penn 1 African American cohort, Yale-Penn 1 European American cohort, SAGE African American cohort, SAGE European American cohort, Yale-Penn 2 African American cohort, Yale-Penn 2 European American cohort, Yale-Penn 3 African American cohort, Yale-Penn 3 European American cohort, and the ICGHD European American cohort. + Indicates effect allele (listed in Table 2) is associated with an increase in cannabis dependence (CAD) criterion count; −, effect allele is associated with a decrease in CAD criterion count; and x, a valid effect estimate could not be obtained. See the Statistical Analysis subsection of the Methods section for an explanation of Yale-Penn 1, 2, and 3.

e

Indicates genome-wide significant P values.

f

Indicates P < .05 in the replication sample.