Table 4.
Concentration of fecal metabolites from control and GOS90-fed mice at the end of the feeding trial. Significant differences (unpaired t-tests p<0.1) between controls and prebiotic-fed mice and between controls and prebiotic responders are bold.
| Metabolite | Control (n =15) |
GOS90 (n = 6) |
GOS90 (Responders) (n = 4) |
p value (control vs GOS90) |
P value (control vs GOS90 responders) |
|---|---|---|---|---|---|
| Acetate | 6.93 ± 4.02 | 4.17 ± 1.65 | 3.52 ± 1.52 | 0.03 | 0.02 |
| Propanoate | 6.12 ± 5.39 | 3.19 ± 2.38 | 3.26 ± 2.90 | 0.17 | 0.16 |
| Isobutyrate | 0.24 ± 0.28 | 0.15 ± 0.19 | 0.08 ± 0.09 | 0.28 | 0.10 |
| Butyrate | 16.13 ± 8.99 | 10.41 ± 5.64 | 9.30 ± 5.41 | 0.10 | 0.06 |
| Valerate | 0.14 ± 0.16 | 0.11 ± 0.09 | 0.04 ± 0.02 | 0.58 | 0.05 |
| Lactate | 7.36 ± 6.90 | 2.22 ± 3.83 | 2.73 ± 4.54 | 0.09 | 0.11 |
| 2-aminobutyrate | 0.14 ± 0.06 | 0.13 ± 0.10 | 0.13 ± 0.13 | 0.90 | 0.99 |
| 4-aminobutyrate | 2.15 ± 0.93 | 1.61 ± 0.85 | 1.33 ± 0.86 | 0.40 | 0.08 |
| Glycerol | 3.62 ± 3.07 | 2.55 ± 2.69 | 3.26 ± 2.97 | 0.71 | 0.81 |
| Succinate | 0.12 ± 0.10 | 0.15 ± 0.08 | 0.16 ± 0.09 | 0.36 | 0.39 |
| Galactose | 0.90 ± 0.71 | 0.64 ± 0.57 | 0.79 ± 0.63 | 0.62 | 0.74 |
| Glucose | 4.64 ± 3.22 | 3.34 ± 3.12 | 4.00 ± 3.57 | 0.57 | 0.71 |