Table 2. Acrophase (± SD) of mRNA levels of clock and clock-controlled genes in the retina and the SCN of control and diabetic animals at 12 weeks post-diabetes.
| Gene | Acrophase (h) |
|||
|---|---|---|---|---|
| Retina |
SCN |
|||
| Control | SZT-diabetic | Control | SZT-diabetic | |
|
Per1 |
- |
11.79±1.5 |
12.7±1.14 |
12.32±1.02 NS |
|
Per2 |
- |
- |
12.07±1.2 |
15.02±1.05 NS |
|
Per3 |
14.7±1.3 |
- |
11.8±1.22 |
13.43±1.17 NS |
|
Bmal1 |
1.4±1.04 |
0.68±2.3 NS |
- |
21.6±1.16 |
|
Clock |
- |
- |
13,7±2.09 |
18.53±1.42 NS |
|
Cry1 |
- |
22.8±1.1 |
10.04±0.8 |
15.10±1.32 * |
|
Rev-erb α |
- |
- |
8.3±0.9 |
11.6±2.09 NS |
|
Ror β |
- |
- |
9.48±1.13 |
- |
|
Dbp |
7.7±1.4 |
7.01±0.9 NS |
- |
- |
| E4Bp4 | - | 18.02±1.52 | - | - |
Acrophase values are determined using Cosinor analysis and test of amplitude to assess goodness of fit. Only rhythms with a significant value are shown. * p≤0.05.