Box-and-whisker plots for plasma S-100B, matrix metalloproteinase-9 (MMP-9), and plasma D-Dimer levels in the poor versus improved clinical status groups both upon admission and at 24 hours after traumatic brain injury (A, B, C). Temporal profiles of median serum S100-B, MMP-9, and plasma D-Dimer levels in the poor versus improved status cohorts upon admission and at 24, 48, and 72 hours after traumatic brain injury (D, E, F).