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. Author manuscript; available in PMC: 2016 Aug 5.
Published in final edited form as: Exp Neurol. 2014 Aug;258:5–16. doi: 10.1016/j.expneurol.2014.01.001

Fig. 1.

Fig. 1

Structural domains of pattern recognition families. The major structural domains of TLRs, NLRs, RLRs, ALRs, and CLRs are depicted above. Note that the NLR family is divided into 4 subfamilies: NLRA, NLRB, NLRC and NLRP. CLRs comprise a large family of receptors, thus only those discussed in this review are shown above. Abbreviations: CARD (caspase recruitment domain), LRR (leucine rich repeat), BIR (baculovirus inhibition of apoptosis protein repeat), PYD (pyrin domain), FIIND (function to find domain), TIR (Toll-IL-1 receptor domain), helicase (DExD/H box helicase domain), CTD (carboxy terminal domain), HIN200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats), L-L (di-leucine motif), 3aa (triad of acidic amino acids), Y (tyrosine-based motif), CRD (carbohydrate recognition domain), ITAM (immunoreceptor tyrosine-based activation motif).