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. Author manuscript; available in PMC: 2016 Aug 5.
Published in final edited form as: Cell Rep. 2016 Jan 21;14(4):896–906. doi: 10.1016/j.celrep.2015.12.083

Figure 6. Site I coordinates VH locus contraction.

Figure 6

A) (Top) Topological sub-domains A–C and VH gene families are drawn approximately to scale. Sites I, II, II.5 and III (orange circles) are aligned with their positions in topological subdomains and with respect to VH gene families. (Bottom) Meta-looping interactions anchored at Sites I, II, II.5 and III (orange circles) are Pax5-dependent (red arc), independent (blue arc) and not tested (black arc). Eμ-dependent loops (green arcs) (Guo et al., 2011a). 3′Eα loops (gray arc) with Eμ (Kumar et al., 2013) and Site I. B,C) Diagrams of sub-domain A, B and C. Sites I, II, and III (orange circles). Dots indicate 3′Eα (red), Eμ (teal). B) Non-B cells: topological sub-domains A, B and C are in an extended configuration. C) In pro-B cells, Site I loops with Sites II and III and with Eμ and 3′Eα to contract the locus.