Table 1.
Risk stratification of patients with MF according to the International Prognostic Scoring System (IPSS),[18] dynamic IPSS (DIPSS),[19] DIPSS plus,[12] and mutation-enhanced IPSS (MIPSS).[20]
| Risk category | Scale | Estimated survival (years) |
|---|---|---|
| IPSS | No. of risk factors a | Median (95% CI) |
| Low | 0 | 11.3 (9.8–15.1) |
| Intermediate-1 | 1 | 7.9 (6.6–9.5) |
| Intermediate-2 | 2 | 4.0 (3.6–4.9) |
| High | ≥ 3 | 2.3 (1.9–2.6) |
| DIPSS | Prognostic score b | Median |
| Low | 0 | NR |
| Intermediate-1 | 1 or 2 | 14.2 |
| Intermediate-2 | 3 or 4 | 4 |
| High | 5 or 6 | 1.5 |
| DIPSS plus | Prognostic score c | Median |
| Low | 0 | 15.4 |
| Intermediate-1 | 1 | 6.5 |
| Intermediate-2 | 2 or 3 | 2.9 |
| High | 4–6 | 1.3 |
| MIPSS | Prognostic score d | Median |
| Low | 0–0.5 | 17.6 |
| Intermediate-1 | 1–1.5 | 7.8 |
| Intermediate-2 | 2–3.5 | 4.3 |
| High | ≥ 4 | 1.6 |
NR: not reached.
aRisk factors include age > 65 years, constitutional symptoms (defined as weight loss > 10% of baseline value in the year preceding diagnosis and/or unexplained fever or excessive sweats persisting for more than 1 month), hemoglobin <10 g/dL, white blood cell count > 25 × 109/L, and peripheral blood blasts ≥ 1%.
bRisk factors (score) include age >65 years (1), constitutional symptoms (1), hemoglobin < 10 g/dL (2), white blood cell count > 25 × 109/L (1), and peripheral blood blasts ≥ 1% (1).
cScoring is based on DIPSS risk categories (low risk, 0 points; intermediate-1 risk, 1 point; intermediate-2 risk, 2 points; high risk, 3 points) and additional risk factors (unfavorable karyotype, 1 point; platelet count < 100 × 109/L, 1 point; transfusion need, 1 point).
dRisk factors (score) include age >60 years (1.5), constitutional symptoms (0.5), hemoglobin < 100 g/L (0.5), platelet count < 200 × 109/L (1.0), triple-negative mutation status (1.5), JAK2 or MPL mutation (0.5), ASXL1 (0.5), and SRSF2 (0.5).