Table 4.
Author | Target | Outcome | Follow-up |
---|---|---|---|
Broggi et al. (1993) [96] | Unilateral VIM DBS | Improved function without tremor | 10 months |
Hooper et al. (2001) [97] | Unilateral junction of ZI and subthalamic region DBS | Long term abolition of the movement disorder after lesioning effect | 44 months |
Umemura et al. (2004) [98] | Unilateral VIM DBS | 52% increase in functional speed in timed task performance trials, and increased independence in activities of daily living | 12 months |
Green et al. (2005) | DBS of right ZI and VOP (ipsilateral) | Increased functional use of left arm | 2 years |
Broggi et al. (2006) [99] | Three patients treated with ZI and VOA/VOP DBS | Marked benefit with all patients regained autonomous self-feeding | 12–36 months |
Foote et al. (2006) [2] | Three patients treated with ipsilateral, dual VIM, and VOA/VOP lead DBS | 38–67% reduction in TRS scores | 12 months, 6 months, and 8 months, respectively |
Franzini et al. (2011) [100] | Nine patients; six unilateral, three bilateral VIM DBS | >50% tremor reduction in all cases | 12 months |
Issar et al. (2013) [38] | Three patients managed with unilateral VIM, one patient with bilateral VIM and One patient with bilateral Gpi | Percentage change in TRS scores was available for three patients and ranged from 14.3% to 56.5% | Mean follow-up 2 years |
Reese et al. (2011) [101] | Unilateral VIM + STN | Reduction in UPDRS III score and TRS score from 25 and 8 to 8 and zero, respectively | 5 years |
Follett et al. (2014) [39] | Bilateral VIM | Tremor reduction from a score of 3 to a score of 1 in the right arm and from 3.5 to 0 in the left arm (TETRAS scale) | 18 months |
GPi, globus pallidus internus; STN, subthalamic nucleus; TETRAS, The Essential Tremor Rating Assessment Scale; TRS, tremor rating scale; VIM, ventral intermedius nucleus; Voa, ventralis oralis anterior nucleus; Vop, ventralis oralis posterior nucleus; Zi, zona incerta.