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. 2016 Aug 1;9:4773–4783. doi: 10.2147/OTT.S103940

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© 2016 Chen et al. This work is published and licensed by Dove Medical Press Limited

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Human HCC cells were protected against armillarikin-induced cytotoxicity by ROS scavenger NAC.

Notes: (A and B) HA22T, (C) Huh7, and HepG2 cells were treated with (A and B) dimethyl sulfoxide (DMSO) or 25 µM or (C) 12.5–50 µM armillarikin with or without 2.5 mM NAC for 48 hours. Then, (A and B) percentage of cells with hypodiploid DNA content and (C) relative number of viable cells (C) were detected and calculated using (A and B) flow cytometry and (C) MTS assay, respectively. OD values of DMSO-treated control cells were designated as 100% activity as a standard. *, P<0.05 and **, P<0.01 (Student’s t-test) compared with Armillarikin plus NAC.

Abbreviations: DMSO, dimethyl sulfoxide; HCC, hepatocellular carcinoma; ROS, reactive oxygen species; MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium; NAC, N-acetyl cysteine.