Table 2.
Associations between different factors and MD slope deterioration
| Clinical variables | MD slope
|
P-valuea | |
|---|---|---|---|
| Deteriorating group (n=70) | Nondeteriorating group (n=86) | ||
| Age (years) | 66.9±11.3 | 62.6±13.9 | 0.0370* |
| Sex, n (%) | |||
| Female | 49 (70.0) | 45 (52.3) | 0.0324* |
| Male | 21 (30.0) | 41 (47.7) | |
| Baseline refraction (D) | −1.9±3.8 | −3.5±3.4 | 0.0048* |
| Initial MD value (dB) | −6.60±4.17 | −7.48±4.23 | 0.1916 |
| MD slope (dB/year) | −0.71±0.45 | −0.01±0.28 | <0.0001* |
| Baseline IOP (mmHg) | 15.7±3.6 | 17.2±3.6 | 0.0107* |
| IOP over follow-up (mmHg) | 13.2±2.2 | 13.5±2.1 | 0.3992 |
| IOP reduction rate (%) | 14.9±13.0 | 20.3±11.8 | 0.0066* |
| Maximum IOP (mmHg) | 16.9±3.8 | 16.7±3.0 | 0.8147 |
| Minimum IOP (mmHg) | 10.2±2.1 | 11.0±2.0 | 0.0161* |
| Long-term IOP fluctuation (mmHg) | 1.7±0.9 | 1.4±0.5 | 0.0309* |
Notes: Data are mean ± SD or n (%); Long-term IOP fluctuation was calculated as the SD of IOP measurements over the follow-up period;
a
t-test except sex (Fisher’s exact test).
*
Statistically significant. Copyright © 2015. Dove Medical Press. Reproduced from Naito T, Yoshikawa K, Mizoue S, et al. Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma. Clin Ophthalmol. 2015;9:1373–1378.25
Abbreviations: D, diopter; dB, decibel; IOP, intraocular pressure; MD, mean deviation; NTG, normal-tension glaucoma; POAG, primary open-angle glaucoma; SD, standard deviation.